Advances in Alzheimer's Research

Nov 3, 1906 · Origin

Alois Alzheimer describes the disease

At a meeting in Tübingen, Alois Alzheimer presents the case of Auguste Deter, describing plaques and tangles in her brain.

May 1, 1984 · Milestone

Amyloid-beta identified

Researchers isolate and sequence the amyloid-beta peptide from plaques, enabling the molecular study of the disease.

Apr 10, 1992 · Milestone

The amyloid cascade hypothesis

A widely cited paper proposes that amyloid accumulation is the initiating event in Alzheimer's disease, shaping drug development for three decades.

Jun 7, 2021 · Turning point

First anti-amyloid antibody approved under accelerated pathway

The FDA grants accelerated approval to aducanumab despite an advisory committee's negative vote, prompting controversy over the evidence standard.

Source: FDA

Jul 6, 2023 · Milestone

Lecanemab receives traditional approval

The FDA converts lecanemab's accelerated approval to traditional approval after a confirmatory trial shows slowing of cognitive decline in early disease.

Source: FDA

Jul 2, 2024 · Milestone

Donanemab approved

The FDA approves a second anti-amyloid antibody for early symptomatic Alzheimer's disease.

Source: FDA